1-(1-取代苯基)-2-(1H-1,2,4-三唑或苯并三唑基)-<i>O</i>-(取代苄基)乙酮肟醚类化合物的合成及抗真菌活性

1-(1-取代苯基)-2-(1H-1,2,4-三唑或苯并三唑基)-O-(取代苄基)乙酮肟醚类化合物的合成及抗真菌活性

摘要: 报道了29个新的1-(1-取代苯基)-2-(1H-1,2,4-三唑或苯并三唑基)-O-(取代苄基)乙酮肟醚类化合物的合成与体外抗菌试验。结果表明,大多数化合物对大部分真菌有抑菌活性,化合物T₁,T₄,T₆,T₁₁,T₁₂,B₁,B₃,B₄和B₆对部分真菌抑菌活性优于或相当于奥昔康唑。

Abstract: Twenty-nine 1-(1-substituted phenyl)-2-(1H-1,2,4-triazol or benztriazol-1-yl)-O-(substituted benzyl) ethanoximes have been synthesized for the first time. Results of preliminary biological test in vitro show that most compounds have antifungal activities against most fungi tested. The antifungal activities of compounds T₁,T₄,T₆,T₁₁ ,T₁₂ ,B₁,B₃,B₄ and B₆ are better than or comparable to the activities of the lead compound oxiconazole against some fungi.