Abstract: AimTo study the benzophenones in the roots of Securidaca inappendiculata Hassk.. MethodsColumn chromatography (including silica gel and Sephadex LH-20) was used to isolate benzophenones whose structures were elucidated by HREI-MS, NMR (1D and 2D) methods. ResultsA new benzophenone was isolated and identified as 2-methoxy-3,4-methylenedioxy-benzophenone (I), along with a known compound 4-hydroxy-2,6-dimethoxy-benzophenone (II). ConclusionCompound I is a new one named as securiphenone B, compound II was isolated from the genus for the first time.