两头尖的化学成分研究

路金才; 徐琲琲; 张新艳; 孙启时

两头尖的化学成分研究

STUDY ON CHEMICAL CONSTITUENTS OF RHIZOME OF Anemone raddeana

摘要

摘要: 目的研究两头尖的化学成分。方法通过硅胶柱色谱,大孔树脂柱色谱及高压液相色谱等方法分离两头尖各部分提取物,根据理化性质和光谱分析鉴定化学结构。结果从两头尖根茎中分离得到9个化合物,分别鉴定为:27-hydroxyolean-12(13)-en-28-oic-acid-3-o-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside (1),五加苷K(eleutheroside K, 2),oleanolic acid-3-O-α-L-rhamnopyranosyl-(1→2)-［β-D-glucopyranosyl-(1→4)］-α-L-arabinopyranoside (3),桦树脂醇(betulin, 4),桦树脂酸(betulic acid, 5),乙酰齐敦果酸(acetyloleamolic acid, 6),卫矛醇(evonymitol, 7),齐敦果酸(oleamolic acid, 8),薯蓣皂苷元(diosgenin, 9)。结论化合物1为新化合物,命名为raddeanoside 12。化合物3～7为首次自该植物中得到。

Abstract: AIMTo investigate the chemical constituents of the rhizome of Anemone raddeana Regel, so as to find new active compounds. METHODSThe ethanol extracts of the rhizome of Anemone raddeana were obtained by silica column, HPLC. The structures of the compounds were elucidated by means of physico-chemical method and spectral analysis (IR, FAB-MS, ¹HNMR, ¹³CNMR, DEPT, ¹H-¹H COSY, HMQC, HMBC). RESULTSNine compounds were isolated and identified as 27-hydroxyolean-12(13)-en-28-oic acid-3-O-α-L-rhamnopyranosyl-(1→2)-α-L-arabinopyranoside (1), eleutheroside K (2), Oleanolic acid-3-O-α-L-rhamnopyranosyl-(1→2)-［β-D-glucopyranosyl-(1→4)］-α-L-arabinopyranoside (3), betulin (4), betulic acid (5), acetyloleamolic acid (6), evonymitol (7), oleamolic acid (8) and diosgenin (9). CONCLUSIONCompound 1 is a new compound, named raddeanoside 12. Compounds 3～7 were isolated from this plant for the first time.

HTML全文

参考文献(0)

施引文献

资源附件(0)