赤芝子实体新三萜化合物的结构鉴定

A NEW TRITERPENE FROM THE FRUITING BODIES OF GANODERMA LUCIDUM

摘要: 目的　对赤芝子实体的化学成分进行研究。方法　利用各种色谱技术进行分离,采用¹HNMR ,¹³CNMR ,¹H-¹HCOSY ,HMQC和HMBC谱进行结构鉴定。结果　从赤芝子实体中分离得到3个化合物,分别鉴定为:lucidenicacidA (1) ,3β,7β-dihydroxy-4,4,14α-trimethyl-11,15-dioxo-5α-chol-8-en-24-oic acid (2 )和lucidenic acid C (3)。结论　化合物2为新化合物,命名为赤芝酸LM₁(lucidenicacidLM₁)。

Abstract: AIM To study the chemical constituents of the fruiting bodies of Ganoderma lucidum. METHODS Individual constituents, isolated and repeatedly purified on silica gel column, were identified by physicochemical constants and structurally elucidated by spectral methods. RESULTS From the alcohol extract, compound 2 was obtained and identified as 3β,7β-dihydroxy-4,4,14α-trimethyl-11,15-dioxo-5α-chol-8-en-24-oic acid. In addition, two known compounds, lucidenic acid A (1) and C (3) were obtained. CONCLUSION Compound 2 is a new triterpene compound.