Abstract: Calcium antagonists are drugs that selectively block potential dependent Ca²⁺ -channel and inhibit Ca²⁺ withdrawal on cell membrane .These drugs are used to treat cardiovascular or cephalovascular diseases. 1,4- Dihydropyridine derivatives in comparison with other drugs, have higher potency and selectivity on Ca²⁺- antagonists.They are vasodilators and hypotensives. In this paper,eleven new dihydropyridine derivatives were prepared with the method of Hantzsch and were characterized on the basis of elemental analysis, intrared spectroscopy (IR) and proton naclear magnetic resonance (¹HNMR).The solubility in water,stability to heat and Ca²⁺-antagonistic activity of the new compounds were reported.