4,4-二(4-氟苯基)丁酸邻位异构物的磺化分离

REMOVAL OF THE ORTHO ISOMER OF 4,4-BIS(4-FLUORO PHENYL) BUTANOIC ACID BY SULFONATION

摘要: 4,4-二(4-氟苯基)丁酸为一重要医药中间体。以4-(4-氟苯基)丁内酯和氟苯为原料,经Feriedel-Crafts反应制备,常因各种条件的影响而改变产物的异构体比例。本文应用磺化反应成功地对4,4-二(4-氟苯基)丁酸中的邻位异构体进行了分离,取得了满意的效果,达到了纯化产品之目的。

Abstract: 4,4-Bis(4-fluorophenyl) butanoic acid is an important pharmaceutical intermediate. It is usually prepared by Friedel-Crafts reaction of 4-(4-fluorophenyl) butyrolactone with fluorobenzene. But the ratio of products is often affected by reaction conditions. By applying sulfonation, the undesired isomer can be successfully removed.