一类具有胰岛素增敏作用的苯并吡喃衍生物的设计和合成

Design and synthesis of a type of benzopyran derivatives with insulin-sensitizing activity

摘要: 在化合物1基础上设计合成了10个新型化合物，用3T3-L1前脂肪细胞对这些化合物进行了胰岛素增敏活性筛选。结果表明化合物10在3T3-L1脂肪细胞模型上表现出较强的促3T3-L1细胞分化活性，提示其可能具有较好的胰岛素增敏作用。

Abstract: Ten novel compounds were designed and synthesized on the basis of compound 1, their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Results showed that compound 10 exhibited strong differentiation-stimulating activity on 3T3-L1 cells model, which indicated that compound 10 may possess well insulin-sensitizing activity.