In recent years, antibiotic resistance of bacteria has become a global health crisis.  Especially, the new class of “superbug” was found in South Asia, which is resistant to almost known antibiotics and causes worldwide alarm.  Through the underlying mechanisms of bacterial pathogenecity, the expression of many pathogen virulence factors is regulated by the process of quorum sensing.  Screening efficient quorum sensing inhibitors is an especially compelling approach to the future treatment of bacterial infections and antibiotic resistance.  This article focuses on bacterial quorum sensing system, quorum sensing screening model for in vitro and evaluation of animal models in vivo, recent research of quorum sensing inhibitors and so on.