水蔓菁中黄酮类化合物的研究

马翠英; 朱开贤; 杨丁铭; 杨峻山; 于德泉

水蔓菁中黄酮类化合物的研究

STUDIES ON CHEMICAL CONSTITUENTS OF VERONICALINA RIIFOLIA PALL.EX LINK.SUB.DILATATA (NAKAI ET KITAGAWA) HONG.

摘要

摘要: 从民间草药玄参科植物水蔓菁Veronica linariifolia Pall. ex Link. sub dilatata(Nakai et Litagawa)Hong.的干燥全草的乙醇提取物中分离得到三个黄酮甙和两个黄酮甙元,其中甙Ⅰ是新化合物,命名为水蔓菁甙(linariifolioside)。根据光谱数据和水解产物分析确定甙Ⅰ的结构为木犀草素-7-O-6″′-O-乙酰基-β-D-葡萄糖基-(1→2)-β-D-葡萄糖甙luteolin-7-O-6″′-O-acetyl-β-D-glucosyl-(1→2)-β-D-glucoside。另外甙Ⅱ,甙Ⅲ以及两个甙元为已知物,分别为木犀草素-7-O-β-D-葡萄糖基(1→2)-β-D-葡萄糖甙luteolin-7-O-β-D-glucosyl(1→2)-β-D-glucoside,Ⅱ和芹黄素-7-O-x-L-鼠李糖甙(apigenin-7-O-α-L-rhamnoside,Ⅲ)、以及木犀草素(luteolin,Ⅳ)和芹黄素(apigenin,Ⅴ)。这些化合物在水蔓菁中均是首次得到。

Abstract: A new flavonoid glycoside, named linariifolioside, C₂₉H₃₂O₁₇ with mp at 232～234℃ (dec.), was isolated from the alcohol extract of the dried whole herb of Veronica linariifoliaPall. ex Link sub. dilatata (Nakai et Kitagawa) Hong. Based on spactral (IR, UV, ¹HNMR, ¹³CNMR and FAB-MS) analysis and hydrolysis products its structure was identified as luteolin-7-O-6″′- O-acetyl-β-D-glucosyl-(1→2)-β-D-glucoside (Ⅰ).In addition, four known compounds, luteolin-7-O-β-D-glucosyl-(1→2)-β-D-glucoside(Ⅱ), apigenin-7-O-α-L-rhamnoside (Ⅲ), luteolin(Ⅳ), and apigenin (Ⅴ) were isolated from the same fraction and identified. These compounds were obtained for the first time from this plant.

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