阿魏酸衍生物的合成及抗血小板聚集活性

Synthesis of ferulic acid derivatives and their inhibitory effect on platelet aggregation

摘要:
以具有活血化瘀作用的中药有效成分阿魏酸为先导物, 设计合成了6个阿魏酸衍生物, 其结构经IR、¹H NMR、¹³C NMR及MS确证。体内药效筛选结果显示, 阿魏酸衍生物对二磷酸腺苷 (ADP) 诱导的血小板聚集具有较好的抑制活性, 其抑制作用明显强于阳性对照药奥扎格雷钠。

Abstract:
Ferulic acid, an useful compound of Chinese traditional medicine, was used as leading compound. Six ferulic acid derivatives were designed and synthesized based on bioisosterism. Their structures were characterized by IR, ¹H NMR, ¹³C NMR and mass spectra. In vivo experiment showed that ferulic acid derivatives had good inhibitory effects on adenosine diphosphate (ADP) induced platelet aggregation, which were significantly higher than that of Ozagrel.