吴茱萸化学成分研究

王奇志; 梁敬钰

吴茱萸化学成分研究

Studies on the chemical constituents of Evodia rutaecarpa (Juss.) Benth.

摘要

摘要: 目的研究吴茱萸Evodia rutaecarpa ［Juss.］ Benth.的化学成分。方法采用溶剂法、硅胶柱色谱和重结晶等方法进行分离纯化，根据化合物的理化性质和光谱数据鉴定结构。结果从吴茱萸中分离得到14个化合物。鉴定出其中的10个化合物，分别为吴茱萸宁碱(evodianinine, 1)、吴茱萸次碱(rutaecarpine, 2)、吴茱萸碱(evodiamine, 3)、吴茱萸酰胺I(wuchuyuamide I, 4)、羟基吴茱萸碱(hydroxyevodiamine, 5)、柠檬苦味素(limonin, 6)、胡萝卜苷(daucosterol, 7)、三十碳酸(triacontanoic acid, 8)、二十九烷(nonacosane, 9)和β-谷甾醇(β-sitosterol, 10)。结论通过UV，IR，ESI-MS，HREIMS，¹HNMR，¹³CNMR，HMQC，HMBC和NOESY分析，鉴定化合物1是新化合物，命名为吴茱萸宁碱。

Abstract: AimTo study the chemical constituents of Evodia rutaecarpa (Juss.) Benth. Methods The crude total alkaloids were enriched by acid-base treatment and solvent extraction. Isolation and purification were carried out by silica gel column chromatography and recrystallization etc. Structural determination of the pure compounds were based on physico-chemical properties and various spectral data analysis (¹HNMR, ¹³CNMR, UV, IR, ¹H-¹H COSY, HMQC, HMBC, ESIMS, HREIMS, NOESY). ResultsFourteen compounds were obtained from Evodia rutaecarpa, ten of them were identified as evodianinine (1), rutaecarpine (2), evodiamine (3), wuchuyuamide I (4), hydroxyevodiamine 5), limonin (6), daucosterol (7), triacontanoic acid (8), nonacosane (9) and β-sitosterol (10). ConclusionCompound 1 is a new alkaloid named evodianinine.

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