Abstract: The effects of dl-(15R)-15 methyl-PGE₂ methyl ester(PG₆E),in experimentalulcers induced by absolute alcohol,HCl,indomethacin,pyloric ligation and chronic acetic acid in ratswere studied.PG₆E at doses 10～80μg·kg^-1 was shown to have significant protective effect.PG₆E(30～60μg·kg^-1)was also found to reduce markedly the acid secretion, pepsin activity,DNAcontent of the juice collected from pylorus ligated stomach of rats and increase markedly the content ofgastric mucosa hexosamine in mice given PG₆E(30～60μg·kg^-1 po for 3 d).At dosesof 40～80μg· kg^-1,PG₆E was able to have no significant effect on gastric emptying time in rats andgastrointestinal tract movement in mice,It appears that PG₆E was shown to inhibit the aggressivefactors and increase the protective factors of gastric mucosa,This may hopefully become a newantiulcer agent.