氯化四乙基铵及维拉帕米对家兔缺血心肌不应期的影响

EFFECTS OF TETRAETHYLAMMONIUM CHLORIDE AND VERAPAMIL ON THE EFFECTIVE REFRACTORY PERIOD OF ISCHEMIC MYOCARDIUM IN RABBITS

摘要: 实验比较了K⁺通道阻断剂氯化四乙基铵(TEA)及Ca²⁺通道阻断剂维拉帕米(verapamil,Ver)对家兔缺血性心室肌不应期(ERP)的影响。结果表明,阻断冠脉10min及30min后,缺血中心区(CIZ)和缺血边缘区(BIZ)心肌ERP比缺血前均明显缩短,而TEA和Ver均能延长急性缺血性心肌的ERP,可能对心肌缺血引起的心律失常有预防作用。

Abstract: The effects of potassium ion Channel blocker TEA and calcium ion channel blokerverapamil on effective refractory period (ERP) of ischemic ventricular muscle were studied in rabbits.The results showed that ERP of the ventricular muscle in central ischemic zone (CIZ) and border is-chemic zone (BIZ) wete shortened, respectively, at 10 min and 30 min after coronary occlusion(P<0. 01). The changes of ERP in TEA--treated and verapamil--treated rabbits after coronary oc-clusion were found to be significantly less than those in untreated rabbits. The results suggest that TEAand verapamil alleviated the degree of ERP shortening after coronary occlusion and may exhibit protec-tive effects on the ischemic myocardium.