杨立新 李杏翠 刘超 肖磊 秦德华 陈若芸. 甘西鼠尾草中化学成分研究J. 药学学报, 2011,46(7): 818-821.
引用本文: 杨立新 李杏翠 刘超 肖磊 秦德华 陈若芸. 甘西鼠尾草中化学成分研究J. 药学学报, 2011,46(7): 818-821.
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YANG Li-Xin, LI Xing-Cui, LIU Chao, Xiao-Lei, QIN De-Hua, CHEN Re-Yun. Chemical constituents from Salvia przewalskii MaximJ. 药学学报, 2011,46(7): 818-821.
Citation: YANG Li-Xin, LI Xing-Cui, LIU Chao, Xiao-Lei, QIN De-Hua, CHEN Re-Yun. Chemical constituents from Salvia przewalskii MaximJ. 药学学报, 2011,46(7): 818-821.
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甘西鼠尾草中化学成分研究

Chemical constituents from Salvia przewalskii Maxim

    摘要
  • 摘要:

    为了研究甘西鼠尾草的化学成分与生物活性之间的相关性, 采用硅胶、Sephadex LH-20、RP-C18  (reverse phase C-18) 等色谱方法进行分离纯化, 通过核磁共振、质谱等波谱分析技术鉴定化合物结构。从甘西鼠尾草的95% 乙醇提取物中分离鉴定了11个化合物, 分别为przewalskin Y-1 (1)、anhydride of tanshinone-ⅡA (2)、sugiol (3)、epicryptoacetalide (4)、cryptoacetalide (5)、arucadiol (6)、1-dehydromiltirone (7)、miltirone (8)、cryptotanshinone (9)、tanshinone-ⅡA (10) 和isotanshinone-Ⅰ(11)。其中化合物1为新化合物, 化合物4和5为一对对映异构体 (1∶3), 化合物4、5、6、8、11为首次从甘西鼠尾草中分离得到。

     

    Abstract:

    The investigation on Salvia przewalskii Maxim was carried out to find the relationship of the constituents and their pharmacological activities.  The isolation and purification were performed by various chromatographies such as silica gel, Sephadex LH-20, RP-C18 column chromatography, etc.  Further investigation on the fraction of the 95% ethanol extract of Salvia przewalskii Maxim yielded przewalskin Y-1 (1), anhydride of tanshinone-ⅡA (2), sugiol (3), epicryptoacetalide (4), cryptoacetalide (5), arucadiol (6), 1-dehydromiltirone (7), miltirone (8), cryptotanshinone (9), tanshinone ⅡA (10) and isotanshinone-Ⅰ(11).  Their structures were elucidated by the spectral analysis such as NMR (Nuclear Magnetic Resonance) and MS (Mass Spectrometry).  Compound 1 is a new compound.  Compounds 4 and 5 are mirror isomers (1∶3).  Compounds 4, 5, 6, 8, 11 were isolated from Salvia przewalskii Maxim for the first time.

     

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