王林, 恽榴红, 张其楷. 胆碱能M受体拮抗剂:2α-(2',2'-二取代基-2'-羟基乙氧基)托品烷光学异构体合成J. 药学学报, 1996, 31(10): 790-794.
引用本文: 王林, 恽榴红, 张其楷. 胆碱能M受体拮抗剂:2α-(2',2'-二取代基-2'-羟基乙氧基)托品烷光学异构体合成J. 药学学报, 1996, 31(10): 790-794.
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L Wang, LH Yun , QK Zhang, . SYNTHESIS OF OPTICAL ISOMERS OF2α-(2',2'- DISUBSTITUTED-2 'HYDROXYETHOXY)TROPANE AS POTENTIAL M-RECEPTOR ANTAGONISTSJ. Acta Pharmaceutica Sinica, 1996, 31(10): 790-794.
Citation: L Wang, LH Yun , QK Zhang, . SYNTHESIS OF OPTICAL ISOMERS OF2α-(2',2'- DISUBSTITUTED-2 'HYDROXYETHOXY)TROPANE AS POTENTIAL M-RECEPTOR ANTAGONISTSJ. Acta Pharmaceutica Sinica, 1996, 31(10): 790-794.
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胆碱能M受体拮抗剂:2α-(2',2'-二取代基-2'-羟基乙氧基)托品烷光学异构体合成

SYNTHESIS OF OPTICAL ISOMERS OF2α-(2',2'- DISUBSTITUTED-2 'HYDROXYETHOXY)TROPANE AS POTENTIAL M-RECEPTOR ANTAGONISTS

    摘要
  • Abstract: Eight 2α-(2',2'-disubstituted-2'-hydroxyethoxy) tropanes(2)were prepared byreactions of enantiomeric and racemic 2α-tropanols with 1,1-disubstituted oxiranes.The optical purityof these diastereoisomers was analyzed by RP-HPLC. The results of preliminary screening indicatedthat the stereochemical variations of these isomers exhibited great influence on the binding affinity forrat brain M-receptor Compounds with 2' R configuration for the tertiary carbon showed greateractivity.

     

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