卷柏中一个新木脂素苷的分离与鉴定

The isolation and identification of a new lignanoside from Selaginella tamariscina (Beauv.) Spring

摘要: 目的研究卷柏的化学成分。方法利用大孔吸附树脂、Sephadex LH-20、硅胶柱色谱进行分离纯化，根据化合物的理化性质和光谱数据鉴定结构。结果从卷柏中分离得到4个化合物，分别鉴定为(7S,8r)-7,8-二氢-7-(4-羟基-3,5-二甲氧基苯基)-8-羟甲基-［1′-(7′-羟基)乙基-5′-甲氧基］苯骈呋喃-4-O-β-D-葡糖苷(命名为卷柏苷C，化合物I)、D-甘露醇(化合物II)、酪氨酸(化合物III)、莽草酸(化合物IV)。结论化合物I为新化合物，化合物II和III为首次从卷柏属植物中分离得到,IV为首次从卷柏中分离得到。

Abstract: AimTo study the chemical constituents of Selaginella tamariscina (Beauv.) Spring. MethodsThe compounds were isolated and purified by macroporous adsorption resin, Sephadex LH-20 and silica gel column chromatography and identified on the basis of their physicochemical and spectral data. ResultsFour compounds were obtained from the n-BuOH fraction of 70% acetone extracts. Their structures were elucidated as (7S,8r)-7,8-dihydro-7-(4- hydroxy-3,5- dimethoxyphenyl)-8-hydroxy-methyl-［1′-(7′-hydroxyethyl) -5′ methoxyl］benzofuran-4-O-β-D-glucopyranoside (tamariscinoside C, I), D-mannitol (II), tyrosine (III), shikimic acid (IV). ConclusionCompound I is a new compound, compounds II and III were obtained from the genius for the first time, compound IV was yielded from the plant for the first time.