杨中铎, 陈华, 王友富, 林力波, 李援朝. 安宫黄体酮母液中两个新化合物的分离与结构鉴定J. 药学学报, 2005, 40(9): 830-833.
引用本文: 杨中铎, 陈华, 王友富, 林力波, 李援朝. 安宫黄体酮母液中两个新化合物的分离与结构鉴定J. 药学学报, 2005, 40(9): 830-833.
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YANG Zhong-duo, CHEN Hua, WANG You-fu, LIN Li-bo, LI Yuan-chao. Isolation and identification of two new epimer from the mother liquid of megestrol acetateJ. Acta Pharmaceutica Sinica, 2005, 40(9): 830-833.
Citation: YANG Zhong-duo, CHEN Hua, WANG You-fu, LIN Li-bo, LI Yuan-chao. Isolation and identification of two new epimer from the mother liquid of megestrol acetateJ. Acta Pharmaceutica Sinica, 2005, 40(9): 830-833.
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安宫黄体酮母液中两个新化合物的分离与结构鉴定

Isolation and identification of two new epimer from the mother liquid of megestrol acetate

    摘要
  • 摘要: 目的研究药物安宫黄体酮中所含的杂质。方法应用柱色谱方法进行分离和纯化，NMR和MS等波谱方法确定结构。结果从安宫黄体酮母液中分离得到2个化合物。结论化合物1和2为新差向异构体，其结构分别鉴定为：17α-氧乙酰基-2β，6α-二甲基孕甾-4-烯-3，20-二酮；17α-氧乙酰基-2α，6α-二甲基孕甾-4-烯-3，20-二酮。

     

    Abstract: AimTo study the impurity in the drug megestrol acetate. MethodsChromatography methods were used to separate the chemical constituents. Their structures were determined by NMR and MS spectral analysis. ResultsTwo new epimers were isolated from the mother liquid of the drug megestrol acetate. ConclusionThese new epimers were identified as 17α-acetoxy-2β,6α-dimethylprega-4-ene-3,20-dione (1) and 17α-acetoxy-2α,6α-dimethylprega-4-ene-3,20-dione (2).

     

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