Abstract:
The Chian-Chung-Tang has been used clinically for treatment of gastric ulceration. It is composed of
Hedysarum polybotrys,Cinnamom carsia,Paeonia lactiflora Gly- cyrrhiza uralensis, Angelica sinenss, Rhizoma Zingiberis, Fructus Zizyphi jujubae, and Saccharum Grannorum. 1.The induction rate of Shay rat ulceration together with the quantity of gastric secretion, free acidity, and total acidity was markedly dereased by Chian-Chung-Tang given subcutaneously, but the same effect was not found, when the drug was given orally. 2.The movement of the stomach of the pigeon as well as the movement of the intestine of the rabbit in situ and that of rabbit and rat
in vitro was depressed by the drug. 3.The drug was also found to antagonize the effect of pilocarpine and prostigmine upon the movement of intestine of rabbit
in situ, and that by acetylcholine and pilocar- pine upon the movement of intestine of rabbit and rat
in vitro. 4.The LD
50 of Chian-Chung-Tang in mice was found to be 48g/kg given sub- cutaneously.