青藤碱衍生物的合成及其抗炎镇痛活性青藤碱衍生物的合成及其抗炎镇痛活性

Synthesis and anti-inflammatory analgesic activities of sinomenine derivatives

摘要: 目的为定向设计合成高效低毒的新一代青藤碱类药物提供线索。方法以青藤碱为先导物,对C环进行结构改造。结果共合成7个衍生物,进行了抗炎镇痛活性的筛选,结果表明,化合物2和5具有较好的抗炎镇痛作用。结论C环结构修饰值得进一步研究。

Abstract: AimTo provide basic data for the synthesis of new sinomenine derivatives. MethodsThe C ring in sinomenine was modified. ResultsSeven compounds were prepared and screened for anti-inflammatory and analgesic activities. Compounds 2 and 5 showed better activities. ConclusionModification of the C ring in sinomenine should be worthy to be studied further.