平其能. 对《药物吸收速率常数的一种简便计算法》一文的几点看法J. 药学学报, 1982, 17(2): 98-100.
引用本文: 平其能. 对《药物吸收速率常数的一种简便计算法》一文的几点看法J. 药学学报, 1982, 17(2): 98-100.
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PING Qi-neng. COMMENTS ON “AN IMPROVEMENT ON THE WAGNER-NELSON METHOD FOR COMPUTING DRUG ABSORPTION RATE CONSTANT”J. Acta Pharmaceutica Sinica, 1982, 17(2): 98-100.
Citation: PING Qi-neng. COMMENTS ON “AN IMPROVEMENT ON THE WAGNER-NELSON METHOD FOR COMPUTING DRUG ABSORPTION RATE CONSTANT”J. Acta Pharmaceutica Sinica, 1982, 17(2): 98-100.
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对《药物吸收速率常数的一种简便计算法》一文的几点看法

COMMENTS ON “AN IMPROVEMENT ON THE WAGNER-NELSON METHOD FOR COMPUTING DRUG ABSORPTION RATE CONSTANT”

    摘要
  • 摘要: 本文对药物吸收速率常数(Kα)的简便计算法的可靠性进行了讨论并对应用中的具体措施提出了不同看法。无论是在特征值左右多取几个血样或是用“二次抛物线拟合”都不能肯定地提高计算精度。对于Kα精度要求较高的药代动力学实验研究,该法还有待进一步改进。

     

    Abstract: Some comments are made on the article "An Improvement on the Wagner—Nelson Method for computing Drug Absorption Rate Constant" (Acta Pharmaceutica Sinica 15:109,1980) The accuracy of Ka calculated according to the method can not be definitely improved either by taking more samples near the time when blood levels approach the characteristic yalues, or by simulating a quadratic parabola.

     

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