<i>N</i>-(4-取代氨基-4-氧代丁酰基)-<i>N</i>-取代甘氨酸的合成

吴勇, 蔡纯一, 龚康孙. N-(4-取代氨基-4-氧代丁酰基)-N-取代甘氨酸的合成J. 药学学报, 1992, 27(9): 717-720.

引用本文:

吴勇, 蔡纯一, 龚康孙. N-(4-取代氨基-4-氧代丁酰基)-N-取代甘氨酸的合成J. 药学学报, 1992, 27(9): 717-720.

Y Wu, CY Cai, KS Gong. SYNTHESIS OF N-(4-SUBSTITUTED AMINO-4-OXOBUTYRYL)-N-SUBSTITUTED GLYCINESJ. Acta Pharmaceutica Sinica, 1992, 27(9): 717-720.

Citation:

Y Wu, CY Cai, KS Gong. SYNTHESIS OF N-(4-SUBSTITUTED AMINO-4-OXOBUTYRYL)-N-SUBSTITUTED GLYCINESJ. Acta Pharmaceutica Sinica, 1992, 27(9): 717-720.

N-(4-取代氨基-4-氧代丁酰基)-N-取代甘氨酸的合成

Abstract: Nine N-(4-substituted amino-4-oxobutyryl) N-substituted glycines expected tohave inhibitory activity on angiotensin-converting enzyme were synthesized. All of the title com-pounds and their t-butyl esters were unreported in the literature. In preliminary test in rats, com-pounds V₂,V₆ and V₇ showed marked hypotensive activity.

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