张秀平, 沈德福, 张秀菊, 陈林, 戴祖瑞, 舒康全. 疟疾防治药物的研究——Ⅵ.2,4-二氨基-6-取代氨基-磺酰基喹唑啉衍生物的合成及其抗疟作用J. 药学学报, 1981, 16(11): 877-880.
引用本文: 张秀平, 沈德福, 张秀菊, 陈林, 戴祖瑞, 舒康全. 疟疾防治药物的研究——Ⅵ.2,4-二氨基-6-取代氨基-磺酰基喹唑啉衍生物的合成及其抗疟作用J. 药学学报, 1981, 16(11): 877-880.
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Zhang Xiuping, Shen Defu , Zhang Xiuju Chen Lin, Dai Zurui , Shu Kangquan, . STUDIES ON ANTIMALARIALS Ⅵ. SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME 2,4-DIAMINO-6-SUBSTITUTED AMINO SULFONYL QUINAZOLINE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(11): 877-880.
Citation: Zhang Xiuping, Shen Defu , Zhang Xiuju Chen Lin, Dai Zurui , Shu Kangquan, . STUDIES ON ANTIMALARIALS Ⅵ. SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME 2,4-DIAMINO-6-SUBSTITUTED AMINO SULFONYL QUINAZOLINE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1981, 16(11): 877-880.
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疟疾防治药物的研究——Ⅵ.2,4-二氨基-6-取代氨基-磺酰基喹唑啉衍生物的合成及其抗疟作用

STUDIES ON ANTIMALARIALS Ⅵ. SYNTHESIS AND ANTIMALARIAL ACTIVITIES OF SOME 2,4-DIAMINO-6-SUBSTITUTED AMINO SULFONYL QUINAZOLINE DERIVATIVES

    摘要
  • Abstract: In the present communication sixteen derivatives of 2, 4-diamino-6-substitutedaminosulfonylquinazolines were synthesized as potential antimalarial agents.Screening tests for therapeutic effect on mice infected with Plasmodium berghei and for prophylactic effect on mice infected with P. yoelii sporozoites,.showed that 2,4-diamino-6-(piperidyl-1) sulfonyl quinazoline acetate (Ⅲ) at daily oral dose of 0.31 mg/kg for 3 consecutive days possess pronounced causal prophylactic activity against P. yoelii.

     

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