薤白甙J,K和L的结构

STRUCTURES OF MACROSTEMONOSIDE J,K AND L FROM ALLIUM MACROSTEMON BUNGE

摘要: 进一步用HPLC自小根蒜(Allium macrostemon Bunge)鳞茎中分得两种新的呋甾皂甙,薤白甙J(1)和薤白甙L(III),以及I的甲基化人工产物薤白甙K(II)。经过化学降解和光谱(¹H-NMR,¹³C-NMR和FAB-MS等)分析,确定其结构分别为:(25R)-26-O-β-D-吡喃葡萄糖基-22-羟基-5β-呋甾-2β,3β,26-三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(I);(25R)-26-O-β-D-吡喃葡萄糖基-22-甲氧基-5β-呋甾-2β,3β,26-.三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(II)和(25R)-26-O-β-D-吡喃葡萄糖基-5β-呋甾-20(22)-烯-26β,3β,26-三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖甙(III)。

Abstract: Further studies by means of HPLC led to the isolation of two new furostanol saponins，macrostemonoside J and L，along with．one artifact macrostemonoside K from Allium macrostemon Bunge.On the basis of chemical evidences and spectral analysis(¹H，¹³C-NMR and FAB-MS)，the structure of macrostemonoside J(I)was elucidated aS(25R)-26-O-β-D-glucopyranosyl-22-hydroxy-5β-furost-2β，3β，26-triol-3-O-β-D-glucopyranosyl(1→2)-β-D-galactopyranoside：macrostemonoside K(II)as(25R)-26-O-β-D-glucopyranosyl-22-methoxy-5β-furost-2β，3β，26-triol-3-O-β-D-glucopyranosyl(1→2)-β-D-galactopyranoside；macrostemonoside L(III)as(25R)-26-O-β-D-glucopyranosyl-5β-furost-20(22)-ene-2β，3β，26-triol-3-O-β-D-glucopyranosyl(1→2)-β-D-galac．topyrancside．