覃兆海, 谢毓元. 铀促排药物研究Ⅵ:2,3-二羟基-4-甲氧羰基苄基胺羧酰胺螯合剂的合成J. 药学学报, 1993, 28(8): 619-622.
引用本文: 覃兆海, 谢毓元. 铀促排药物研究Ⅵ:2,3-二羟基-4-甲氧羰基苄基胺羧酰胺螯合剂的合成J. 药学学报, 1993, 28(8): 619-622.
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ZH Qin, YY Xie. STUDIES ON URANIUM MOBILIZATION AGENTS VI: SYNTHESIS OF 2,3-DIHYDROXY-4-CARBOMETHOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTSJ. Acta Pharmaceutica Sinica, 1993, 28(8): 619-622.
Citation: ZH Qin, YY Xie. STUDIES ON URANIUM MOBILIZATION AGENTS VI: SYNTHESIS OF 2,3-DIHYDROXY-4-CARBOMETHOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTSJ. Acta Pharmaceutica Sinica, 1993, 28(8): 619-622.
shu

铀促排药物研究Ⅵ:2,3-二羟基-4-甲氧羰基苄基胺羧酰胺螯合剂的合成

STUDIES ON URANIUM MOBILIZATION AGENTS VI: SYNTHESIS OF 2,3-DIHYDROXY-4-CARBOMETHOXYBENZYL AMINOCARBOXYLIC ACID AMIDES CHELATING AGENTS

    摘要
  • Abstract: In searching for new chelation therapy drugs against uranium intoxication, a series of N-carboxymethyl-N- (substituted carbamoylmethyl)- 2, 3- dihydroxy- 4- carbomethoxybenzylamine was synthesized starting with o-vanillin. The effect on detoxieation of UO2 (NO3)2, CuSO4 and NiCl2 in mice was tested. Some of them (IVa, IVd, IVf and IVg) were shown to be good antidotes for acute uranium intoxication, but all were less effective for Cu2+ and Ni2+.

     

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