The study is to prepare taste masking and enteric-coated clarithromycin granules by melting and fluid bed coating technology.  Clarithromycin and matrix materials were melted at a certain temperature, and then made into particles by fluidized bed coating.  X-ray powder diffraction and scanning electron microscopy were used to identify the crystal and morphology of drug loading granules.  In vitro dissolution method was used for the observation of the drug release behavior.  The results showed that the drug particles size range was 0.2 − 0.6 mm; the crystal form of clarithromycin in the granule did not change; enteric-coated granules accumulated release in 0.1 mol·L⁻¹ hydrochloric acid in 2 h was less than 10%, while in pH 6.8 phosphate buffer in 1 h was more than 80%.  The taste masking and enteric-coated clarithromycin granules not only have good taste masking effect, but also have a good release behavior.  It is expected to have better clinical application.