环孢素A固体分散物一些物性的研究

STUDIES ON SOME PHYSICAL CHARACTERISTICS OF CYCLOSPORINE A (CyA) SOLID DISPERSIONS

摘要: 以泊洛沙姆188或聚乙烯吡咯烷酮为载体,分别应用熔融—溶剂法或溶剂法制备了环孢素A—泊洛沙姆、环孢素A—聚乙烯吡咯烷酮固体分散物,其比例为10∶90～90∶10。通过粉末X-射线衍射、热台显微镜、差示扫描量热法等研究其物理化学性质的变化,为药物处方前的研究提供可靠的科学依据。

Abstract: In this paper, poloxamer and PVP were used as carriers. CyA-poloxamer and CyA-PVP solid dispersions were prepared using the melting-solvent method or solvent method, respectively. The percentage compositions of the solid dispersions ranged from 10∶90 to 90∶10. Hot stage microscopy, powder X-ray diffraction and differential scanning calorimetry were used to examine the physical-chemical characteristics of the solid dispersions to provide some reliable and scientific basis for preformulation of CyA.