褚季瑜, 丁捷飞, 刘寅曾, 朱宝亭, 褚云鸿. LHRH类似物的设计和合成J. 药学学报, 1989, 24(2): 95-98.
引用本文: 褚季瑜, 丁捷飞, 刘寅曾, 朱宝亭, 褚云鸿. LHRH类似物的设计和合成J. 药学学报, 1989, 24(2): 95-98.
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JY Ch.u, JF Ding, YZ Liu, BT Zhu , YH Chu, . DESIGN AND SYNTHESIS OF LHRH ANALOGSJ. Acta Pharmaceutica Sinica, 1989, 24(2): 95-98.
Citation: JY Ch.u, JF Ding, YZ Liu, BT Zhu , YH Chu, . DESIGN AND SYNTHESIS OF LHRH ANALOGSJ. Acta Pharmaceutica Sinica, 1989, 24(2): 95-98.
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LHRH类似物的设计和合成

DESIGN AND SYNTHESIS OF LHRH ANALOGS

    摘要
  • 摘要: 为了寻找新的高效LHRH类似物,设计并合成了带有(D-Trp6、desGly10)-LHRHEA,(D-Arg6,desGly10)-LHRHEA变换5位残基的六个类似物。并应用体外黄体细胞培养法测定了它们的生理活性。

     

    Abstract: In the hope to find new superagonists of LHRH, here we report the synthesis of six analogs by changing residue 5 of D-Trp6 (or D-Arg6), desGly10-LHRH-EA. For the convenience of comparison, the known compound D-Trp6, desGIy10-LHRH-EA was also synthesized.These peptides were synthesized by Merrifield's solid phase method.The agonistic activities of these analogs are also reported.

     

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