马学惠, 赵元昌, 尹镭, 徐瑞龄, 韩德五, 王明时. 乌苏酸对实验性肝损伤的防治作用J. 药学学报, 1986, 21(5): 332-335.
引用本文: 马学惠, 赵元昌, 尹镭, 徐瑞龄, 韩德五, 王明时. 乌苏酸对实验性肝损伤的防治作用J. 药学学报, 1986, 21(5): 332-335.
MA Xue-Hui, ZHAO Yuan-Chang, YIN Lei, XU Rui-Ling, HAN De-Wu , WANG Ming-Shi, . STUDIES ON THE PREVENTIVE AND THERAPEUTIC EFFECTS OF URSOLIC ACID (UA) ON ACUTE HEPATIC INJURY IN RATSJ. Acta Pharmaceutica Sinica, 1986, 21(5): 332-335.
Citation: MA Xue-Hui, ZHAO Yuan-Chang, YIN Lei, XU Rui-Ling, HAN De-Wu , WANG Ming-Shi, . STUDIES ON THE PREVENTIVE AND THERAPEUTIC EFFECTS OF URSOLIC ACID (UA) ON ACUTE HEPATIC INJURY IN RATSJ. Acta Pharmaceutica Sinica, 1986, 21(5): 332-335.

乌苏酸对实验性肝损伤的防治作用

STUDIES ON THE PREVENTIVE AND THERAPEUTIC EFFECTS OF URSOLIC ACID (UA) ON ACUTE HEPATIC INJURY IN RATS

  • 摘要: 实验表明乌苏酸能使急性肝损伤大鼠SGPT及肝甘油三脂下降,血清甘油三脂、β脂蛋白及肝糖原含量增加,并能减轻肝细胞变性、坏死。推测乌苏酸为陆英抗肝损伤的主要成分。

     

    Abstract: The preparation of Sambucus chinesis Lindl was found to have therapeutic effects on patients with acute hepatitis, UA is a components isolated from this plant. The results of the present investigation indicate that acute liver injury induced by CCl4 in rats could be prevented by UA. It was found that the SGPT and liver triglyceride levels were decreased, serum β-lipoprotein and liver glycogen contents were increased. The degeneration and necrosis of the liver cells were less severe in UA treated than in the controls. It appears, therefore, that UA is the main active constituent of Sambucus chinesis Lindl for the prevention of hepatic injury in rats.

     

/

返回文章
返回