曾广方, 柯荣棠. 马兜铃属植物的化学(Ⅱ)异马兜铃酸与马兜铃酸的关系J. 药学学报, 1958, 6(3): 174-177.
引用本文: 曾广方, 柯荣棠. 马兜铃属植物的化学(Ⅱ)异马兜铃酸与马兜铃酸的关系J. 药学学报, 1958, 6(3): 174-177.
TSENG KWONG-FONG KU YUNG-T'ANG, . CHEMICAL STUDIES ON ARISTOLOCHIA SPECIES(Ⅱ)RELATION BETWEEN ISOARISTOLOCHIC ACID AND ARISTOLOCHIC ACIDJ. Acta Pharmaceutica Sinica, 1958, 6(3): 174-177.
Citation: TSENG KWONG-FONG KU YUNG-T'ANG, . CHEMICAL STUDIES ON ARISTOLOCHIA SPECIES(Ⅱ)RELATION BETWEEN ISOARISTOLOCHIC ACID AND ARISTOLOCHIC ACIDJ. Acta Pharmaceutica Sinica, 1958, 6(3): 174-177.

马兜铃属植物的化学(Ⅱ)异马兜铃酸与马兜铃酸的关系

CHEMICAL STUDIES ON ARISTOLOCHIA SPECIES(Ⅱ)RELATION BETWEEN ISOARISTOLOCHIC ACID AND ARISTOLOCHIC ACID

  • Abstract: In our first report, the yellowish crystalline constituent, m. p. 275, C17H11O7N (Ⅰ) was isolated from A. debilis S. et Z. and it was proposed to be isoaristolochic acid (Ⅱ), which was originally isolated from A. indica by Krishnaswamy et al. (J. Ind. Chem. Soc., 12, 476, 1935). However, during our further studies of its structure, it was found that the compound formed derivatives identical to those derived from aristolochic acid (Ⅲ), such as decarboxylated compound (Ⅳ) C10H11O5N, m. p. 208, and a hydrogenated compound (V), C17H11O4N, m. p. 313. Furthermore, the UV-spectra of (Ⅳ) was practically the same as the decarboxylated compound obtained by Pailer et al. from A. clementis (Monat., 87, 249, 1956). Neither the aristolochic acid methyl ester nor its decarboxylated compound showed depression in melting point when mixed with their respective crystals from A. clementis. According to these facts, isoaristolochic acid and aristolochic acid ought to be identical. The authors wish to express their gratitude to Dr. M. Pailer of the University of Vienna, Austria for his kindness to send us the aristolochic acid methyl ester and its decarboxylated compound.

     

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