马学惠, 赵元昌, 尹镭, 韩德五, 冀春萱. 齐墩果酸防治实验性肝损伤作用的研究J. 药学学报, 1982, 17(2): 93-97.
引用本文: 马学惠, 赵元昌, 尹镭, 韩德五, 冀春萱. 齐墩果酸防治实验性肝损伤作用的研究J. 药学学报, 1982, 17(2): 93-97.
MA Xue-hui, ZHAO Yuan-chang, YIN Lei , HAN De-wu, . STUDIES ON THE EFFECT OF OLEANOLIC ACID ON EXPERIMENTAL LIVER INJURYJ. Acta Pharmaceutica Sinica, 1982, 17(2): 93-97.
Citation: MA Xue-hui, ZHAO Yuan-chang, YIN Lei , HAN De-wu, . STUDIES ON THE EFFECT OF OLEANOLIC ACID ON EXPERIMENTAL LIVER INJURYJ. Acta Pharmaceutica Sinica, 1982, 17(2): 93-97.

齐墩果酸防治实验性肝损伤作用的研究

STUDIES ON THE EFFECT OF OLEANOLIC ACID ON EXPERIMENTAL LIVER INJURY

  • 摘要: 齐墩果酸对CCl4引起的大鼠急性肝损伤有明显的保护作用。表现在药物能使血清GPT明显下降;肝内甘油三酯蓄积量减少;肝细胞变性、坏死明显减轻,糖原蓄积增加;根据超微结构观察,肝细胞内线粒体肿胀与内质网囊泡变减轻。

     

    Abstract: Oleanolic acid was found to be effective in the prevention of experimental liver injury induced by injection of CCl4 in rats. The results of this investigation indicate that the SGPT level and liver triglyceride of ratsintoxicated with CCl4 were markedly decreased, the degeneration and necrosis of liver cells were also significantly diminished, the glycogen content in the liver cells was increased, the damaged mitochondrial and endoplasmic structure of liver cells were restored by treatment with Oleanolic acid.The results both biochemical and morphological investigations suggest that Oleanolic acid has a potent protective action on CCl4 induced liver injury.

     

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