郭宗儒. 三嗪类化合物对L.casei离体二氢叶酸还原酶活性和L.casei细胞生长抑制作用的定量相关关系J. 药学学报, 1983, 18(1): 33-38.
引用本文: 郭宗儒. 三嗪类化合物对L.casei离体二氢叶酸还原酶活性和L.casei细胞生长抑制作用的定量相关关系J. 药学学报, 1983, 18(1): 33-38.
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GUO Zong-ru. QUANTITATIVE CORRELATIONS OF THE INHIBITORY EFFECTS OF ITRIAZINES ON THE ISOLATED DIHYDROFOLATE REDUCTASE FROM LACTOBACILLUS CASEI CELLS AND THE CELLS IN CULTUREJ. Acta Pharmaceutica Sinica, 1983, 18(1): 33-38.
Citation: GUO Zong-ru. QUANTITATIVE CORRELATIONS OF THE INHIBITORY EFFECTS OF ITRIAZINES ON THE ISOLATED DIHYDROFOLATE REDUCTASE FROM LACTOBACILLUS CASEI CELLS AND THE CELLS IN CULTUREJ. Acta Pharmaceutica Sinica, 1983, 18(1): 33-38.
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三嗪类化合物对L.casei离体二氢叶酸还原酶活性和L.casei细胞生长抑制作用的定量相关关系

QUANTITATIVE CORRELATIONS OF THE INHIBITORY EFFECTS OF ITRIAZINES ON THE ISOLATED DIHYDROFOLATE REDUCTASE FROM LACTOBACILLUS CASEI CELLS AND THE CELLS IN CULTURE

    摘要
  • 摘要: 三嗪类化合物抑制L.casei细胞生长作用和抑制离体的二氢叶酸还原酶活性,经多重回归分析建立的活性相关方程,表明在抑制拮抗株和敏感株生长作用时,较抑制离体酶需有更高的疏水性,与Hansch分析的推论是一致的。

     

    Abstract: Using the multiple regression analysis method in quantitative structure-activity relationships, the inhibitions of dihydrofolate reductase isolated from L. casei cells and that of the intact L. casei cells in culture by 4, 6-diamino-1, 2-dihydro-2,2-dimethyl-1-(3-substituted phenyl)-s-triazines were correlated.

     

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