Abstract: A new animal medel of hypergiycema and hyperlidemia was establislied bytreating normal Kunming mice with alloxan(iv);After different time intervals ,the levels of bloodglucose(BG)and serum triglyceride(TG)were determined.Forty-eight h after alloxanadministration ,the BG increased significantly,and the level of serum triglyceride reached maxium。The levels of blood glucose,serum triglyceride,cholesterol(CHOL )and free fatty acid(FFA )forvehicle treated mice were about 3.1,4.0,1.1,and 1. 7 times those of normal Kunming mice, respec-tively,To evaluate the new animal model, four drugs were use Two of them were antihyperglyce-mic drugs,metformin and a Recipe of Chinese Herbs(RC The other two were antihyperlipldemicagents ,clofibrate and fenofibrate。All drugs showed positlve effects on this kind of alloxan-diabeticKunming mice.It can be concluded that this kind of alloxan-treated Kunming mice is useful for testinghypoglycemic and hypolipidemic drugs。