<i>n</i>-(4-芳酰胺基苯基)甲磺酰胺类化合物的合成及抗炎活性

n-(4-芳酰胺基苯基)甲磺酰胺类化合物的合成及抗炎活性

摘要: 目的研究n-(4-芳酰胺基苯基)甲磺酰胺类化合物的抗炎作用。方法以对硝基苯胺为起始原料经三步反应合成目标化合物，并以二甲苯致小鼠耳肿胀模型测试目标化合物的抗炎活性。结果共合成11个化合物，经IR，¹HNMR和MS光谱确证结构；初步药理试验结果显示大部分化合物对二甲苯致小鼠耳肿胀具有较强的抑制作用。结论n-(4-芳酰胺基苯基)甲磺酰胺类化合物具有较强的抗炎活性。

Abstract: AimTo study the anti-inflammatory activity of n-(4-arylamidophenyl)methanesulfonamide derivatives. MethodsThe target compounds were synthesized from P-nitroaniline via three steps and were evaluated for anti-inflammatory activity with the model of xylene-induced ear edema in mice. ResultsEleven compounds were obtained and confirmed by IR, ¹HNMR and MS. Some compounds were shown to have significant anti-inflammatory activity. Conclusionn-(4-arylamidophenyl)methanesulfonamide showed appreciable anti-inflammatory activity.