韩光范, 欧阳杰, 王进军, 焦淑萍, 姜贵吉. 6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成及镇痛作用J. 药学学报, 1992, 27(4): 256-260.
引用本文: 韩光范, 欧阳杰, 王进军, 焦淑萍, 姜贵吉. 6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成及镇痛作用J. 药学学报, 1992, 27(4): 256-260.
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GF Han, J Ouyang, JJ Wang, SP Jiao, GJ Jiang. SYNTHESIS AND ANALGESIC ACTION OF 6,7-METHYLENEDIOXY—1(2H,4H)-ACRIDONE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1992, 27(4): 256-260.
Citation: GF Han, J Ouyang, JJ Wang, SP Jiao, GJ Jiang. SYNTHESIS AND ANALGESIC ACTION OF 6,7-METHYLENEDIOXY—1(2H,4H)-ACRIDONE DERIVATIVESJ. Acta Pharmaceutica Sinica, 1992, 27(4): 256-260.
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6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成及镇痛作用

SYNTHESIS AND ANALGESIC ACTION OF 6,7-METHYLENEDIOXY—1(2H,4H)-ACRIDONE DERIVATIVES

    摘要
  • 摘要: 报道13个6,7-亚甲二氧基-1(2H,4H)-吖啶酮衍生物的合成。初步药理实验表明:合成的化合物均有不同程度的镇痛作用,其中化合物Ⅱe的镇痛效力最强。

     

    Abstract: Thirteen derivatives of 6, 7-methylenedioxy-1 (2H, 4H)-acridonewere prepared. The structures of all the compounds synthesized were characterized byelemental analysis, IR and 1HNMR spectra. Compounds Ⅱa, Ⅱb, Ⅱd, Ⅱe, Ⅱf increased significantly the pain threshold using thehot- plate method.

     

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