Abstract: In the present communication seven 2-substituted-1, 3-bis-(benzyl)-tetrahydroimidazoles(Ⅲ_a-Ⅲ_g) and four 2-substituted-1, 3-bis-(benzyl)-hexahydropyrimidines(Ⅳ_a-Ⅳ_d) were synthesized as potential antitumour agents. These compounds were obtained by condensing N, N'-bis-(benzyl)-ethylenediamine(or trimethylenediamine) with appropriate benzaldehyde in the presence of a few drops of piperidine. Preliminary pharmacological tests showed that compounds Ⅲ_a, Ⅲ_b and Ⅲ_c exhibited moderate inhibition(about 50%) against sarcoma 180 in mice.