马尾松松针中木脂素类成分的分离与鉴定

Isolation and structure identification of lignans from pine needles of pinus massoniana Lamb.

摘要: 目的研究松科植物马尾松(Pinus massoniana Lamb.)松针的化学成分。方法利用色谱技术分离纯化,根据化合物的理化性质和光谱数据进行结构鉴定。结果从马尾松松针水煎液的正丁醇部位分离得到3个化合物,分别鉴定为:(7S,8R)-3′,4,9′-三羟基-4-甲氧基-9-O-莽草酰基-7,8-二氢苯并呋喃-1′-丙基新木脂素(massonianoid A,I),(7S,8R)-4,9,9′-三羟基-3,3′-二甲氧基-7,8-二氢苯并呋喃-1′-丙基新木脂素(II),4,4′,8-三羟基-4,4′-二甲氧基-9-木脂内酯(III)。结论化合物I为新化合物,II和III为首次从本植物中分离得到。

Abstract: AimTo study the chemical constituents from the water-extracts of pine needles of Pinus massoniana Lamb. MethodsChromatographic techniques were used to separate and purify compounds. Their physico-chemical properties and spectral data (UV, IR, MS, ¹H-¹H, 13C-¹H NMR, DEPT, HMBC etc.) were used to elucidate the structures. ResultsThree lignans were isolated from the N-BuOH fraction of water-extracts. Their structures were identified as (7S,8R)-3′,4,9′-tridihydroxy-4-methoxy-9-O-shikimoyl-7,8-dihydrobenzofuran-1′-propylneolignan (massonianoid A, I), (7S,8R)-4,9-dihydroxy-3,3′-dimethoxy-7,8-dihydrobenzofuran-1′-propylneolignan (II) and 4,4′,8-trihydroxy-4,4′-dimethoxy-9-lignanolide (III). ConclusionCompound I is a new compound. While II and III were isolated from this plant for the first time.