Protective effects of two different extracts of TSCA (total saponins from Cicer arietinum) were studied on kidney of T2DM rats.  The diabetic model group was established with high calorie feeding and small dose injection of streptozotocin (STZ, 45 mg·kg⁻¹).  DM rats were randomly assigned to model group (feed with propylene glycol 1 mL/100 g), TSCA high dose group (300 mg·kg⁻¹), TSCA low dose group (100 mg·kg⁻¹) and normal control group (feed with propylene glycol 1 mL/100 g).  After four weeks treatment with TSCA I and II, the levels of FPG, FIns, BUN, Scr, ATII, ET-1, TXB₂ and 6-keto-PGF_1α in blood and the activities of SOD, GSH-PX and MDA in kidney were analyzed by biochemical methods.  After four weeks treatment with TSCA II, the levels of FPG, FIns, BUN, Scr, ATII and ET-1 were reduced significantly; and the ratios of TXB₂ to 6-keto-PGF_1α and SOD were effectively alleviated in TSCA II group.  While there   is no significant change on FPG and BUN in comparison to the rats treated with TSCA I, Scr, ATII, ET-I, GSH-PX and SOD were alleviated.  The results suggest that TSCA II could be used to reduce FPG and FIns.  According to the result of vasoactive substances index, TSCA II is more effective than TSCA I on renal protection of DM rats.