战书莉, 张纯贞. 联苯双酯代谢产物——4-羟基联苯双酯合成的研究J. 药学学报, 1992, 27(8): 582-588.
引用本文: 战书莉, 张纯贞. 联苯双酯代谢产物——4-羟基联苯双酯合成的研究J. 药学学报, 1992, 27(8): 582-588.
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SL Zhan, CZ Zhang. STUDIES ON THE SYNTHESIS OF DIMETHYL 4-HYDROXY-4’-METHOXY-5,6,5’,6’-BISMETHYLENEDIOXY BIPHENYL2,2’-DICARBOXYLATE——AN ESSENTIAL METABOLITE OF BIPHENYL DIESTERJ. Acta Pharmaceutica Sinica, 1992, 27(8): 582-588.
Citation: SL Zhan, CZ Zhang. STUDIES ON THE SYNTHESIS OF DIMETHYL 4-HYDROXY-4’-METHOXY-5,6,5’,6’-BISMETHYLENEDIOXY BIPHENYL2,2’-DICARBOXYLATE——AN ESSENTIAL METABOLITE OF BIPHENYL DIESTERJ. Acta Pharmaceutica Sinica, 1992, 27(8): 582-588.
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联苯双酯代谢产物——4-羟基联苯双酯合成的研究

STUDIES ON THE SYNTHESIS OF DIMETHYL 4-HYDROXY-4’-METHOXY-5,6,5’,6’-BISMETHYLENEDIOXY BIPHENYL2,2’-DICARBOXYLATE——AN ESSENTIAL METABOLITE OF BIPHENYL DIESTER

    摘要
  • 摘要: 4-羟基联苯双酯(Ⅱ)为联苯双酯(Ⅰ)的代谢产物。本文报道了2-溴-3,4-亚甲二氧基-5-苄氧基苯甲酸甲酯(6)的合成探讨,并将6与2-溴-3,4-亚甲二氧基-5-甲氧基苯甲酸甲酯(8)进行不对称的Ullmann缩合反应,再氢解制得化合物Ⅱ。

     

    Abstract: This paper reports the synthesis of dimethyl 4-hydroxy-4′ -methoxy-5,6,5′, 6′-bis-methylenedioxybiphenyl-2,2′-dicarboxylate (Ⅱ). Various conditions for bromination were tried to findthe best one for synthesis of the key intermediate compound 6. After Ullmann condensation of 6 with8 and hydrogenolysis,the title compound Ⅱ was obtained. It was proved to be identical with the isolat-ed metabolite of biphenyl diester by spectral data.

     

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