张培棪, 王继光, 梁重栋, 郭韡. 藏红花的药理研究 Ⅰ.对子宫、动情周期和毒性的观察J. 药学学报, 1964, 11(2): 94-100.
引用本文: 张培棪, 王继光, 梁重栋, 郭韡. 藏红花的药理研究 Ⅰ.对子宫、动情周期和毒性的观察J. 药学学报, 1964, 11(2): 94-100.
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CHANG PEI-YEN WANG CHI-KWANG LIANG JONG-DONG KUO WEI, . STUDIES ON THE PHARMACOLOGICAL ACTION OF ZANG HONG HUA(CROCUS SATIVUS L.)——Ⅰ.EFFECTS ON UTERUS AND OESTROUS CYCLEJ. Acta Pharmaceutica Sinica, 1964, 11(2): 94-100.
Citation: CHANG PEI-YEN WANG CHI-KWANG LIANG JONG-DONG KUO WEI, . STUDIES ON THE PHARMACOLOGICAL ACTION OF ZANG HONG HUA(CROCUS SATIVUS L.)——Ⅰ.EFFECTS ON UTERUS AND OESTROUS CYCLEJ. Acta Pharmaceutica Sinica, 1964, 11(2): 94-100.
shu

藏红花的药理研究 Ⅰ.对子宫、动情周期和毒性的观察

STUDIES ON THE PHARMACOLOGICAL ACTION OF ZANG HONG HUA(CROCUS SATIVUS L.)——Ⅰ.EFFECTS ON UTERUS AND OESTROUS CYCLE

    摘要
  • 摘要: 本文报导藏红花(Crocus sativus L.)对子宫的作用、对动情周期的影响及毒性试验的结果,藏红花各种提液对兔和狗等的子宫,包括孕与未孕、离体与在体及整体的子宫瘘管,均表现兴奋作用。对受孕子宫较未孕子宫作用强。甘肃产红花(Carthamus tinctorius L.)对子宫的作用远较藏红花为弱,藏红花兴奋子宫的机制,似与子宫肌和神经都有关系。用含藏红花0.23—2%的食物饲喂正常小白鼠三星期,观察到阴道全角化的持续时间可延长至3—4天,停药后作用迅速消失。藏红花煎剂在小白鼠灌胃试验,LD50为20.7克/公斤。小白鼠饲料中混入2%的藏红花飼喂一个月以上开始出现体重减轻等毒性症状,剂量再增加时则出现死亡。甘肃产红花的毒性比藏红花小。

     

    Abstract: 1. Various extracts of Zang Hong Hua were studied on isolated horns of uteri of guinea-pigs, rabbits, and dogs, both gravid and non-gravid. 2. The stimulating action of various extracts of Zang Hong Hua occurred in uteri of all animals, whether gravid or not. The excised organs and intact uteri gave similar effects. The mechanism of action was discussed. The effect seems to be both myogenic and neurogenic. 3. When mice were fed a diet containing 0.23-2% Zang Hong Hua powder for three weeks, the duration of complete cornification of vaginal epithelium was prolonged from normal 1-2 days to 3-4 days. 4. The oral LD50 of the decoction in mice was found to be 20.7 g(Crude drug)/kg.

     

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