王保钧, 邓泳, 马银凤, 雷兴翰. 血吸虫病化学治疗的研究——ⅩⅩⅩⅣ.α-氯-β-(5-硝基-2-呋喃)丙烯酰胺类及其乙烯噁二唑类衍生物的合成J. 药学学报, 1987, 22(12): 923-928.
引用本文: 王保钧, 邓泳, 马银凤, 雷兴翰. 血吸虫病化学治疗的研究——ⅩⅩⅩⅣ.α-氯-β-(5-硝基-2-呋喃)丙烯酰胺类及其乙烯噁二唑类衍生物的合成J. 药学学报, 1987, 22(12): 923-928.
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WANG Bao-Jun, DENG Yong, MA Yin-Feng , LEI Xing-Han, . CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅣ. THE SYNTHESIS OF DERIVATIVES OF α-CHLOROβ-(5-NITRO-2-FURYL) ACRYLAMIDES AND α-CHLORO-β-( 5-NITRO-2-FURYL ) VINYL/OXADIA ZOLESJ. Acta Pharmaceutica Sinica, 1987, 22(12): 923-928.
Citation: WANG Bao-Jun, DENG Yong, MA Yin-Feng , LEI Xing-Han, . CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅣ. THE SYNTHESIS OF DERIVATIVES OF α-CHLOROβ-(5-NITRO-2-FURYL) ACRYLAMIDES AND α-CHLORO-β-( 5-NITRO-2-FURYL ) VINYL/OXADIA ZOLESJ. Acta Pharmaceutica Sinica, 1987, 22(12): 923-928.
shu

血吸虫病化学治疗的研究——ⅩⅩⅩⅣ.α-氯-β-(5-硝基-2-呋喃)丙烯酰胺类及其乙烯噁二唑类衍生物的合成

CHEMOTHERAPEUTIC STUDIES ON SCHISTOSOMIASIS ⅩⅩⅩⅣ. THE SYNTHESIS OF DERIVATIVES OF α-CHLOROβ-(5-NITRO-2-FURYL) ACRYLAMIDES AND α-CHLORO-β-( 5-NITRO-2-FURYL ) VINYL/OXADIA ZOLES

    摘要
  • Abstract: Synthesis of 35 new compounds of α-chloro-β-(5-nitro-2-furyl) acrylamides and 5-α-chloro-β-(5-nitro-2-furyl ) vinyl-oxadiazoles by known methods are reported. In preliminary test in mice 10 compounds were found to possess pronounced activity against Schistosomiasis japonica. Among these Ⅰ12, Ⅰ13, Ⅰ14, Ⅰ20, Ⅱ1 and Ⅱ8 were shown to be the most effective.

     

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