噻吩并四氢吡啶衍生物的合成及其抗血小板聚集活性研究

Synthesis of thienopyridine derivatives and its anti-platelet activity in vivo

摘要:
为了寻找新型的ADP受体拮抗剂类抗血栓药物, 合成了18个未见文献报道的噻吩并四氢吡啶衍生物, 化合物结构经¹H NMR和MS确证。大鼠体内抗血小板聚集活性研究表明, 化合物C1的活性优于阳性对照药噻氯匹定, 值得进一步深入研究; 化合物A4、B2、C4和C7均有不同程度的抑制血小板聚集的活性。

Abstract:
To explore novel ADP receptor inhibitors with anti-thrombotic activity, eighteen compounds were synthesized and their structures were confirmed by ¹H NMR and MS. The results showed that the activity of compound C1 was superior to ticlopidine in platelet aggregation inhibition tests in vivo and worthy for further investigation. Compounds A4, B2, C4 and C7 possessed moderate platelet aggregation inhibitory activities.