中药白花前胡根中香豆素白花前胡素(E)的分离鉴定

ISOLATION AND IDENTIFICATION OF COUMARIN PRAERUPTORIN E FROM THE ROOT OF THE CHINESE DRUG PEUCEDANUM PRAERUPTORUM DUNN (UMBELLIFERAE)

摘要: 从白花前胡(Peucedanum praeruptorum Dunn)根的醚提取物中除分得已知香豆素白花前胡丙素和另一种结晶外,还分得一种具有生理活性的香豆素单体,命名为(+)白花前胡素(E)(+)praeruptorin E。经元素分析、紫外、红外、质谱、核磁、气相及水解产物的鉴定,证明白花前胡素(E)为(+)3′-当归酰基-4′-异戊酰基-顺式-凯林酮(+)3′-angeloyl-4′-isovalerylcis-khellactone,此香豆素对小白鼠具有耐缺氧作用。关于其他成分,将另有报告。

Abstract: A pharmacologically active new compound, praeruptorin E and two known praeruptorin C and crystal (Ⅱ) were first isolated from the root of the Chinese drug Peucedanum praeruptorum Dunn.The structure of praeruptorin E was elucidated as(+)3'-angeloyl-4'-isovalerylcis-khellactone by spectral (UV; IR, MS, NMR) and chemical (hydrolysis) studies Praeruptorin E was shown to increase tolerance to anoxia in intact mice.