葛大伦, 梁晓天, 卢玉华, 祁建新. 氧蒽酮-2-羧酸类衍生物及二苯酮类衍生物的合成J. 药学学报, 1987, 22(11): 822-826.
引用本文: 葛大伦, 梁晓天, 卢玉华, 祁建新. 氧蒽酮-2-羧酸类衍生物及二苯酮类衍生物的合成J. 药学学报, 1987, 22(11): 822-826.
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GE Da-Lun, LIANG Xiao-Tian, LU Yu-Hua, , QI Jian-Xin. SYNTHESIS OF DERIVATIVES OF XANTHONE-2-CABOXYLIC ACIDS AND DIPHENYL KETONESJ. Acta Pharmaceutica Sinica, 1987, 22(11): 822-826.
Citation: GE Da-Lun, LIANG Xiao-Tian, LU Yu-Hua, , QI Jian-Xin. SYNTHESIS OF DERIVATIVES OF XANTHONE-2-CABOXYLIC ACIDS AND DIPHENYL KETONESJ. Acta Pharmaceutica Sinica, 1987, 22(11): 822-826.
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氧蒽酮-2-羧酸类衍生物及二苯酮类衍生物的合成

SYNTHESIS OF DERIVATIVES OF XANTHONE-2-CABOXYLIC ACIDS AND DIPHENYL KETONES

    摘要
  • 摘要: 本文合成了一系列取代的氧蒽酮-2-羧酸化合物和二苯酮类化合物。用大鼠的被动皮肤过敏(简称PCA)反应试验抗过敏活性,显示了化合物(Ⅱ)注射有活性,化合物(Ⅳ,Ⅴ)口服有活性。

     

    Abstract: A series of substituted xanthone-2-carboxylic acids and diphenyl ketones were synthesized and bioassayed for antiallergic activity, using the passive cutaneous anaphylaxis (PCA) reation in rats. The results showed that i. v. compound Ⅱ and p. o. compounds Ⅳ and Ⅴ have inhibitory activity on PCA.

     

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