制首乌中两个新化合物

TWO NEW COMPOUNDS OF RADIX POLYGONI MULTIFLORI PREPARATA

摘要: 目的：研究制首乌(Radix Polygoni multiflori Preparata)化学成分。方法：应用硅胶、Sephadex、反相硅胶柱色谱对制首乌正丁醇萃取部分中化学成分进行分离纯化，应用理化常数测定和光谱(IR,MS,¹HNMR,¹³CNMR,2D-NMR)分析技术鉴定结构。结果：分离并鉴定了5个单体化合物：大黄素甲醚-8-O-β-D-葡糖苷(Ⅰ)、大黄素-8-O-β-D-葡糖苷(Ⅱ)、决明蒽酮-8-O-β-D-葡糖苷(Ⅲ)、6-甲氧基-2-乙酰基-3-甲基-1,4-萘醌-8-O-β-D-葡糖苷(Ⅳ)、2,3,5,4′-四羟基二苯乙烯-2-O-(2″-O-乙酰基)-β-D-葡糖苷(Ⅴ)。结论：Ⅳ和Ⅴ为新化合物。

Abstract: AIM: To investigate the chemical constituents of Radix Polygoni multiflori Preparata. METHODS: Compounds were isolated from the n-BuOH extract with column chromatography of silica gel, Sephadex, ODS, and compounds were identified on the basis of spectral analysis (IR, EI-MS, FAB-MS, ¹HNMR, ¹³CNMR, 2D-NMR) and phytochemical properties. RESULTS: Five compounds were isolated and identified as: physcion-8-O-β-D-glucopyranoside (Ⅰ), emodin-8-O-β-D-glucopyranoside (Ⅱ), torachrysone-8-O-β-D-glucopyranoside (Ⅲ), 6-methoxyl-2-acetyl-3-methyl-1,4-naphthoquinone-8-O-β-D-glucopyranoside (Ⅳ), 2,3,5,4′-tetrahydroxystilbene-2-O-(6″-O-acetyl)-β-D-glucopyranoside (Ⅴ). CONCLUSION: Ⅳ and Ⅴare two new compounds.