线性变温法预测硫酸链霉素化学稳定性

STUDIES ON THE CHINESE DRUG, ACONITINE SPP ⅩⅩ. ALKALOIDS FROM ACONITUM FINETIANUM HAND-MAZZ

摘要: 本文用线型变温法,同时用经典恒温法,对同一批号硫酸链霉素水溶液进行稳定性预测,得到硫酸链霉素在pH=6.50水溶液中的分解活化能分别为E=33 kcal·mol^-1及E=34 kcal·mol^-1;室温速度常数分别为k_20℃=5.7×10^-6h^-1及k_20℃=5.0×10^-6h^-1。

Abstract: Two known alkaloids, lappaconitine and ranaconitine and a new alkaloid, named finaconitine, C₃₂H₄₄N₂O₁₀, m.p. 220-221℃ have been isolated from the root of Aconitum finetianum Hand-Mazz.The chemical Structure of finaconitine was assigned as 10-β-hydroxyranaconitine by ¹³C NMR, ¹H NMR, IR, UV, and MS spectral data.