卟啉胆甾酯及其金属络合物的合成、结构与光敏活性

黄素秋; 刘德伟; 姜兆慈; 郭煜; 李冰

黄素秋, 刘德伟, 姜兆慈, 郭煜, 李冰. 卟啉胆甾酯及其金属络合物的合成、结构与光敏活性J. 药学学报, 1989, 24(11): 817-821.

引用本文:

黄素秋, 刘德伟, 姜兆慈, 郭煜, 李冰. 卟啉胆甾酯及其金属络合物的合成、结构与光敏活性J. 药学学报, 1989, 24(11): 817-821.

SQ Huang, DW Liu, ZC Jiang, Y Guo , B Li, . SYNTHESIS AND PHOTODYNAMIC ACTION OF PORPHYRINCHOLESTEROL ESTER AND THEIR METAL COMPLEXESJ. Acta Pharmaceutica Sinica, 1989, 24(11): 817-821.

Citation:

SQ Huang, DW Liu, ZC Jiang, Y Guo , B Li, . SYNTHESIS AND PHOTODYNAMIC ACTION OF PORPHYRINCHOLESTEROL ESTER AND THEIR METAL COMPLEXESJ. Acta Pharmaceutica Sinica, 1989, 24(11): 817-821.

卟啉胆甾酯及其金属络合物的合成、结构与光敏活性

SYNTHESIS AND PHOTODYNAMIC ACTION OF PORPHYRINCHOLESTEROL ESTER AND THEIR METAL COMPLEXES

摘要

摘要: 本文报道了七个卟啉胆甾酯和它们的金属络合物的合成、结构测定及其对喉癌细胞(HEP_-2)的光动力作用试验结果。化合物的DSC测定发现6-Cu和8-Fe有液晶转变峰,对HE-P_-2细胞的光敏致死率6,7,10比合合的水溶性卟啉(TPPS、TAMP)高,而比HpD低。

Abstract: The synthesis of cholesterol-porphyrin and their metal complexes are reported. The cytotoxicity to cancer cell on exposure to light is also described.

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