Abstract: To study the effects of the constituents L 6a and L 10 from leaves of Luffa cylindrica Roem on learning memory disfunction and seduce electric potential (SEP) in cerebral ischemia rats. METHODS: The learning memory behavior was determined by active avoidance response (AAR) in shuttle box and the seduce electric potential (SEP) in cortical body sensation region was measured by SYD₄₂₂₈ physiological experiment system in model of cerebral ischemia rat after injecting experimental drugs in cerebral ventricle (icv). RESULTS: Treatment with L-6a at dosage of 0.5 mg·kg^-1 obviously promoted acquirement of AAR in cerebral ischemia rats (P<0.05) and at doses of 0.5 and 0.25 mg·kg^-1 obviously postponed the fading away of AAR (P<0.05). Treatment with L-6a (0.5 mg·kg^-1 ) was shown to relief the descent of SEP wave amplitude and the prolongation of SEP latent period after cerebral ischemia (P<0.05). When blood was poured into brain again, both L-6a and L-10 were shown to markedly amplify SEP wave amplitude (P<0.05) and shorten latent period of SEP. CONCLUSION: L-6a was found to obviously promote recovery of cerebral disfunction in rats.