陈秋霞 曾苏. 斑马鱼在药物代谢中的研究进展J. 药学学报, 2011,46(9): 1026-1031.
引用本文: 陈秋霞 曾苏. 斑马鱼在药物代谢中的研究进展J. 药学学报, 2011,46(9): 1026-1031.
shu
CHEN Qiu-Xia, CENG Su. Research progress of zebrafish used in drug metabolismJ. 药学学报, 2011,46(9): 1026-1031.
Citation: CHEN Qiu-Xia, CENG Su. Research progress of zebrafish used in drug metabolismJ. 药学学报, 2011,46(9): 1026-1031.
shu

斑马鱼在药物代谢中的研究进展

Research progress of zebrafish used in drug metabolism

    摘要
  • 摘要:

    斑马鱼作为模式生物已经被广泛地用于药物研发的各个过程中。斑马鱼中有细胞色素P450酶(cytochrome P450, CYP450)、尿苷二磷酸葡萄糖基转移酶 (uridine 5'-diphospho-glucuronosyltransferase, UGT) 等多种药物代谢酶和核受体如孕烷X受体 (pregnane X receptor, PXR)、芳香烃受体 (aryl hydrocarbon receptor, AHR) 等的表达。本文综述了斑马鱼中主要的药物代谢酶和核受体的表达情况, 以及在药物等外源物代谢研究中的进展。

     

    Abstract:

    Zebrafish is widely used as a model organism in the process of drug discovery.  It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc.  This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.

     

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