黄花蒿内生菌<i>Myrothecium roridum</i>IFB-E091产生的一个新吲哚衍生物

黄花蒿内生菌Myrothecium roridumIFB-E091产生的一个新吲哚衍生物

摘要: 从黄花蒿内生菌Myrothecium roridum IFB-E091固体发酵产物中分离获得3个化合物, 分别被鉴定为: (S)-(-)-N-2-(3-Hydroxy-2-oxo-2, 3-dihydro-1H-indol-3-yl)-ethyl-acetamide (1)、N-(4-hydroxyphenethyl)acetamide (2) 和asperfumoid (3), 其中化合物1为新吲哚衍生物。体外细胞毒活性测定表明, 化合物1对人肝癌细胞SMMC- 7721和人宫颈癌细胞HeLa没有明显的抑制活性。

Abstract: Three compounds were isolated from solid culture of endophyte Myrothecium roridum IFB-E091 in Artemisia annua. Their structures were determined as (S)-(-)-N-2-(3-hydroxy-2-oxo-2,3-dihydro-1H-indol- 3-yl)-ethyl-acetamide (1), N-(4-hydroxyphenethyl)acetamide (2) and asperfumoid (3), in which compound 1 was a new indole derivative. In cytotoxicity assay, the compound 1 had no obvious inhibition activity in human hepatoma cell line SMMC-7721 and human cervical carcinoma cell line HeLa.