李彩萍, 龚康孙, 蔡纯一, 赵满琼. N-(1-乙氧羰基-3-苯氨甲酰基丙基)甘氨酰甘氨酸衍生物的合成J. 药学学报, 1994, 29(10): 730-738.
引用本文: 李彩萍, 龚康孙, 蔡纯一, 赵满琼. N-(1-乙氧羰基-3-苯氨甲酰基丙基)甘氨酰甘氨酸衍生物的合成J. 药学学报, 1994, 29(10): 730-738.
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CP Li, KS Gong, CY Cai , MQ Zhao, . SYNTHESIS OF N-(1-CARBETHOXY-3-PHENYLCARBAMOYLPROPYL) GLYCYL GLYCINE DERIV ATIVESJ. Acta Pharmaceutica Sinica, 1994, 29(10): 730-738.
Citation: CP Li, KS Gong, CY Cai , MQ Zhao, . SYNTHESIS OF N-(1-CARBETHOXY-3-PHENYLCARBAMOYLPROPYL) GLYCYL GLYCINE DERIV ATIVESJ. Acta Pharmaceutica Sinica, 1994, 29(10): 730-738.
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N-(1-乙氧羰基-3-苯氨甲酰基丙基)甘氨酰甘氨酸衍生物的合成

SYNTHESIS OF N-(1-CARBETHOXY-3-PHENYLCARBAMOYLPROPYL) GLYCYL GLYCINE DERIV ATIVES

    摘要
  • 摘要: 报道4个N-(1-1-乙氧羰基-3-(对甲)苯氨甲酰基丙基甘氨酰｝-N-取代甘氨酸(XI1～4)和5个1-1-乙(或甲)氧羰基-3-(对甲)苯氨甲酰基丙基-4-取代-1,4-哌嗪-2,5-二酮(XII1～5)共9个估计有血管紧张素转化酶抑制活性化合物的合成和鉴定。所有这些化合物及9个相应的酯(X1～9)均未见文献报道。药理初试结果,化合物XII2,XII5,XI4和XII1均有较强降压活性。

     

    Abstract: Four N-(1-carbethoxy-3-phenylcarbamoylpropyl)glycyl glycine derivatives(XI1～4)and five 1-(1-carbethoxy-3-phenylcarbamoyl)propyl-1,4-piperazine-2,5-dione derivatives(XII1～5)expected to have inhibitory activity on angiotensin-converting enzyme were synthesized.All of the compounds mentioned above and nine corresponding esters(X1～9)were not reported in literature.In preliminary test in rats,compounds XII2 and XII5 showed marked hypotensive activity.

     

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